Peptide research profile

Epithalon

Also known as Epitalon · AEDG

A synthetic tetrapeptide from the Russian peptide-bioregulator program. Telomerase and telomere findings are mainly in vitro; high-quality independent human longevity evidence is absent.

  • Longevity & mitochondria
Preclinical-heavy2 referencesEducational use

Dosing literacy

Dosing & scaling, explained

The 1 mg daily for 10 days row is a recorded bioregulator convention, not a validated human longevity regimen. This is educational source context—not a protocol or recommendation.

Scaling framework

How sourced amounts are organized

  1. Starting pointNot clinically established
    No validated titration window

    There is no regulator-approved starting dose for this research use. A low-looking number is not automatically safe.

  2. Recorded preset1 mg / day
    Calculator library reference

    This is the range represented in the in-app protocol library. It describes the source record; it does not validate the regimen.

  3. Higher exposureNo validated upper exposure
    Risk and uncertainty increase

    Higher exposure is not established as more effective. Human pharmacokinetic and long-term safety data may be absent.

Drug amount and device markings are different quantities. The calculator converts mass into volume, syringe units, or pen clicks.

Schedule literacy

Patterns described in source material

  • 10-day block in the preset

    The cadence represented by the recorded calculator presets.

  • Repeat every 4 months in the source row

    Published experiments may use a different route, formulation, timing, or population and should not be treated as interchangeable.

  • No universal schedule

    No single schedule has been validated across products or research contexts.

Clinical context

No regulator-grade human dose-ranging study establishes a schedule for telomere or longevity outcomes.

Research best practices

Storage, handling and interpretation

Lyophilized material

Keep cold, dry, and protected from light according to the manufacturer certificate or validated lab SOP.

After reconstitution

Use sterile technique, refrigerate as validated, and avoid repeated freeze–thaw cycles.

Traceability

Record lot, concentration, preparation date, and the identity/purity documentation used by the lab.

Research orientation

What researchers are exploring

These themes describe recurring questions in published research. They are not claims of effectiveness or recommendations for use.

  • 01

    Telomere biology

    Cell studies report hTERT/telomerase activity and telomere-length changes.

  • 02

    Circadian and pineal research

    Early literature examines melatonin rhythms and pineal-associated aging.

  • 03

    Gerontology

    Small regional studies report aging-related endpoints with limited independent replication.

  • 04

    Gene regulation

    Laboratory studies explore chromatin and gene-expression effects of short peptides.

Evidence map

What the current evidence can support

Study models remain visible so laboratory and animal findings are not mistaken for established human outcomes.

  • In vitro

    Human-cell telomerase study

    A 2003 paper reported telomerase activation and telomere elongation in cultured human somatic cells.

  • In vitro

    Independent 2025 cell replication

    A later study reported dose-dependent telomere effects across normal and cancer cell lines.

  • Review

    Clinical longevity claims remain unproven

    Cellular telomere findings do not show lifespan extension or clinical benefit in people.

Recorded protocol library

Amounts recorded for Epithalon

These amount records are independent from vial strength, reconstitution volume and measuring device. A recorded source is not the same as study backing, and these values are not recommendations.

  • 01

    Recorded reference

    1 mg

    Sign in for schedule, duration and source context.

  • 02

    Dose · upper endpoint

    5 mg

    Sign in for schedule, duration and source context.

Technical reference

Identity, limitations and unknowns

Molecular profile

Class
Synthetic tetrapeptide bioregulator
Sequence
AEDG
Amino acids
4
Approx. MW
390.4 Da
Origin / design
Designed from research on pineal peptide extracts

Important limitations

  • Most publications originate from a small interconnected research network.
  • No large independently replicated randomized human trial establishes anti-aging benefit.
  • Telomerase activation has context-dependent theoretical risks and is not inherently beneficial.
  • A calculator preset is a recorded research convention, not a recommendation or evidence of clinical benefit.
  • Identity, purity, sterility, and stability can vary substantially outside regulated manufacturing.
  • Route, formulation, and population can make results from one study inapplicable to another use.

Curated sources

2 curated references

  1. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cellsBulletin of Experimental Biology and Medicine · 2003 · In vitro
  2. Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activityBiogerontology · 2025 · In vitro

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